In the Middle Ages, the fortified castle of Saissac was reinforced and enlarged, becoming one of the largest fortresses in the region. It served as a residence for local lords and a refuge for the villagers in case of attack. The castle became an important stronghold for the region's defense against enemy invasions. Over the following centuries, the village of Saissac was the scene of numerous conflicts and wars. During the Crusades, the village was captured and recaptured by both the Crusaders and the Muslims. During the Wars of Religion, the village was captured and recaptured by both Catholics and Protestants. Finally, during the French Wars of Religion, the village was captured and recaptured by royalist and Protestant troops.